(6) Does it mean that it is mandatory to have a genetic check prior to starting treatment or is it that, if any patient suffers again, you have an excuse?

This is not so. Looking at the history of the patient itself, it becomes clear that the patient might have this type of gene. If after developing a symptom, the patient loses vision in a very short time, there are chances that he/she will need repeat courses due to such a genetic makeup.